Pyrex Journal of Research in Environmental Studies (PJRES)

March 2015 Vol. 2(2), pp. 013-021

Copyright © 2015 Pyrex Journals




Review Paper


Stability Constants of Rhenium (V) Metal Complexes with Selected Medicinal Drugs


Gamal A.H. Gouda

Faculty of Science, Al-Azhar University, Assiut 71524, Egypt

Corresponding Author E-mail: ggouda73@mail.ru

Accepted 20th December, 2014



Abstract


Stability constants of rhenium (V) metal complexes with selected medicinal drugs Adenosine (ADE), isoniazid (ISO) and metformin hydrochloride (MET) have been determined using a pH metric titration technique in aqueous hydrochloric acid media at different temperature (293, 303, 313 and 323 K) and an ionic strength of 0.2 M. It is observed that rhenium (V) metal ion forms 1:1 and 1:2 complexes with these drugs. The proton-ligand and metal-ligand stability constants were determined by Calvin-Bjerrum pH titration technique as modified by Irving and Rossitti. The thermodynamic parameters such as, Gibb’s free energy change (∆G), entropy change (∆S) and enthalpy change (∆H) associated with the complexation reactions were calculated. The formations of metal complexes were found to be spontaneous, exothermic in nature and favorable at lower temperature.

Keywords: Medicinal drugs, Rhenium (V) complexes, Formation constants, Thermodynamic parameter.

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