Pyrex Journal of Medicinal Plant Research (PJMPR)

March 2016 Vol. 2(1), pp. 001-007

Copyright 2016 Pyrex Journals

Full Length Research Paper

The Potential Effects of Reishi Mushroom (Ganoderma lucidum) Consumption on Bone Health Indices and Serum Minerals Profile Disorders Induced by CCl4 on Rats

Yousif A. Elhassaneen*, Sherif S. Ragab and Mona S. Salman

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt.

Corresponding Author E-mail:

Accepted 03 March, 2016


The modern pharmacological therapy is costly and associated with multiple side effects resulting in patient non-compliance. Thus there is a need to explore alternative therapies particularly from herbal sources as these are cost effective and possess minimal side effects. Therefore, the purpose of this study was to elucidate the potential effects of reishi mushroom (Ganoderma lucidum) consumption on bone indices and serum minerals profile disorders induced by CCl4 on rat. Treatment of animals with CCl4 caused a significant decreased (p≤0.05) in serum minerals profile (Fe, -31.14%, Ca, -21.36% and P, -25.76%) and bone health indices [bone mineral density (BMD), -19.20%, %), bone G- protein (BG-P), -37.54%and bone mineral content (BMC), -30.56%] compared to normal controls. Supplementation of the rat's diet with reishi mushroom powder (RMP) (1.0 to 5.0 g/100g) improved their serum minerals content and bone indices. The rate of improving was elevated with the increasing of the RMP concentration. In conclusion, the present work has been undertaken to present scientific information on an medicinal plant, reishi mushroom, which has been documented for its antiosteoporotic activity. So, we recommended RMP by concentrations ranged 1-5% % amount to be included in our daily diets, drinks and food supplementation.

Keywords: Iron, calcium, phosphorous, bone mineral density, bone mineral content, Bone G-protein.

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