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Pyrex Journal of Medicinal Plant Research (PJMPR)

July 2016 Vol. 2(2), pp. 8-20

Copyright 2016 Pyrex Journals

Full Length Research Paper


Effect of Selected Plant Parts Extracts on Liver Injuries Induced by CCl4 in vitro


Yousif A. Elhassaneen*, Sherif S. Ragab and Amal A. Saleh

Department of Nutrition and Food Science, Faculty of Home Economics, Minoufiya University, Shebin El-Kom, Egypt.

Corresponding Author E-mail: yousif12@hotmail.com

Accepted 28th June, 2016



Abstract


The objective of this study is to highlight the potential effects of selected plant parts extracts [Sweet violet blossoms (SVB), marjoram leaves (ML), red onion skin (ROS) and orange peel (OP)] individually or to work together to improve the liver injuries induced by CCl4 in vitro. Fish liver homogenate and human lymphocytes cultures were used as in vitro biological model systems. The data indicated that CCl4 induced many adverse cytotoxic, immunotoxic and genotoxic effects including lysosomal and mitochondrial dysfunctions, cell membrane integrity and decreasing in protease activity in fish liver homogenate and DNA damage in human lymphocytes cultures. Co-treatment of liver homogenate with CCl4 and the tested selected plant parts extracts as well as their mixture by concentration 0.75% exhibited many therapeutic effects through decreasing the rates of all those adverse effects. That decreasing rates in different toxic effects was depending on the type of the plant parts applied. The highest therapeutic effect was recorded for the mixture of the selected plant parts extracts (OP+SVB+ROS+ML by equal parts) followed by ROS, ML, OP and SVB, respectively. Such data indicated that there has been considerable interest in the role of complementary and alternative medicines for the prevention/treatment of liver injury induced in humans by many environmental toxins.

Keywords: Fish liver homogenate, human lymphocytes, toxicity, sweet violet blossoms, marjoram leaves, onion skin, orange peel.

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