SUBMIT MANUSCRIPT

Pyrex Journal of Microbiology and Biotechnology Research (PJMBR)

March 2017 Vol. 3(1), pp. 1-9

Copyright 2017 Pyrex Journals




Full Length Research Paper


Bacterial Uropathogens And Their Antibiotic Susceptibility Pattern At Dessie Regional Health Laboratory


Solomon Yilma Mitiku

Bahir Dar University College of Natural Science, Department of Biology, Bahir Dar, Ethiopia. Ethiopian Institute of Agricultural Research, Ambo Plant Protection Research Center, Ambo, Ethiopia , P.O. Box 37.

Corresponding Author E-mail: solomonyilma509@gmail.com

Accepted 9th March, 2017



Abstract


Urinary tract infection (UTI) is one of the most common bacterial infections encountered by clinicians in developing countries which can involve the urethra, bladder, and kidney. UTI affects all age groups, but women are more susceptible than men. Antibiotic resistance of urinary tract pathogens has increased worldwide. Knowledge of the antibiotic resistance patterns of uropathogens in specific geographical locations is an important factor for choosing an appropriate empirical antimicrobial treatment. Therefore, the aim of this study was to determine the type and antibiotic resistance pattern of bacterial urinary pathogens isolated from patients referred to Dessie Regional Health Research Laboratory from September 2013 to August 2014. A prospective cross sectional study was conducted and urine samples were collected using the mid-stream "clean catch" method from 156 clinically-suspected cases of urinary tract infections and tested bacteriologically using standard procedures. Antimicrobial susceptibility test was performed using Kirby-Bauer disk diffusion method. From 156 urine specimens, bacterial isolates were found in 49 (31.4%). The most common pathogens isolated were Escherichia coli (55.1%), Klebsiella spp. (16.3%), Proteus spp. (12. %) P. aeruginosa (4.1%) S. aureus (6.1%), Enterococcus spp. (4.1%) and Citrobacter spp. (2.0%). All isolates in the study showed high rate of resistance to ampicillin, tetracycline, penicillin, vancomycin, cloxacillin and amoxicillin (>72.9%) however, the majority of bacterial isolates were sensitive to ciprofloxacin, ceftriaxone, nitrofurantoin, and norfloxacin. In this study E. coli was the most prominent bacterial isolates with increased prevalence in adult, female and married patients particularly. History of catheterization was significant risk factors for UTI. The present study also showed a high incidence of resistance to most antimicrobial agents tested. As drug resistance among bacterial pathogens is an evolving process, routine surveillance and monitoring studies should be conducted for providing knowledge to physicians on the updated and most effective empirical treatment of UTIs.

Keywords: Uropathogen, Antimicrobial susceptibility, Dessie.

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