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Pyrex Journal of Biomedical Research (PJBR)

May 2017 Vol. 3 (4), pp. 29-33

ISSN: 2579-1222

Copyright 2017 Pyrex Journals




Full Length Research Paper


Assessment of Liver Function Tests among Alcoholisms in Sudan


Asaad Ahmed Mustafa* and AbdElkarim A. Abdrabo

Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, AL-Neelain University, Sudan.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 13th April, 2017



Abstract


Background: Alcoholism is an important health problem all over the world. Liver function tests are important tools in diagnosing alcohol abuse and identifying the stages of alcoholic liver disease. Objective: This study aimed to assess the liver function tests among Alcoholism in Sudan. Materials and method: This was cross-sectional study, which conducted in Dar El Salam, Omdurman, Khartoum state during the period from November-December 2016, 43 Alcoholic subjects were enrolled in this study, all cases were alcoholic drinkers and had no background of liver disease. Albumin (ALB), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and gamaglutamyl transaminase (GGT) levels were measured by advanced chemistry analytical system Mindray BS200 at friendship hospital. SPSS was used to analyze the data. Results: The results showed that, Alcohol subjects had significantly higher AlB, AST, GGT and TP compared to normal reference value p-value (0.005, 0.008, 0.001, 0.008) respectively. 84% of alcoholic subjects had higher levels of AST, 23% had high levels of ALT and 81% had high levels GGT. Alcoholic subjects daily drinkers had higher levels of ALP and GGT compared to those who drink sometimes p-value (0.015 ,0.002) respectively. Alcoholic subjects sedately life style had higher levels of AST and GGT compared to those who had active lifestyles p-value (0.005, 0.001) respectively. AST, ALT, ALP and GGT were positively correlated with the quantity of alcohol consumed. Also, there were positive correlation between AST, ALT and ALP with duration of alcohol. Conclusion: This study concludes that, Alcoholism had significantly higher Alb, AST, GGT and TP. The quantity of alcohol consumed correlated positively with AST, ALT, ALP and GGT. Duration of alcoholic positively correlated with AST, GGT and TP.

Keywords: Alcoholism, liver, enzymes.

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