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Pyrex Journal of Biomedical Research (PJBR)

March 2017 Vol. 3 (3), pp. 25-28

ISSN: 2579-1222

Copyright 2017 Pyrex Journals




Full Length Research Paper


Levels of HS-CRP among Patients with Cardiovascular Disease Attending Emergency Units in Khartoum Hospitals


Alaa Kamal Mubark* and AbdElkarim A. Abdrabo

Department of Chemistry, Faculty of Medical laboratory Sciences, Al-Neelain University, Sudan.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 29th February, 2017



Abstract


Background and Objective: The role of inflammatory markers and its relation with risk factors of coronary artery disease is important issue. One of these markers is hs-CRP that has been indicated to increase in patients with coronary artery disease (CVD). The objective of this study was to determine serum levels of hs-CRP among patients with CVD attending emergency units in Khartoum state Hospital. Methods: In the present study, 60 patients met with the criteria of the study were selected out of 260 patients attending ER with chest pain suggestive angina. Levels of hs-CRP and Troponin I (TnI) using immunoassay method. Results: The included patients with CVD were 60 (68.3% male, and 31.7% female), with mean age of (5217.55 years). Abnormal ECG was found in 38 patient of them 37 were positive troponin. The remained were with normal ECG (22) out of them 5 patients with positive troponin, and 17 patient with negative troponin. The best adjusted cut off value for CRP for diagnosis of AMI was 40 mg/l with sensitivity of 98% and specificity of 90%. Conclusion: Our data suggest a strong correlation between hs-CRP levels and CVD, the best cut off value is 40 mg/l for diagnosis of AMI.

Keywords: Coronary artery disease, hsC-reactive protein, UA, ECG.

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