SUBMIT MANUSCRIPT

Pyrex Journal of Biomedical Research (PJBR)

January 2017 Vol. 3 (1), pp. 1-6

ISSN: 2579-1222

Copyright 2017 Pyrex Journals




Full Length Research Paper


Effects of Antipsychotic Drugs on Serum Biochemical Tests


Maha Makeen, Joiria Abdelraheem, Shiraz Osman, Eman Abass, Khalid M. Adam and AbdElkarim A. Abdrabo*

Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 23rd January, 2017



Abstract


Background: Accumulating evidence suggests that the typical and atypical antipsychotic drugs have serious metabolic disturbance. Objective: To compare the effects of atypical (Olanzapine) and typical (Haloperidol) antipsychotic medications on lipid profiles, plasma parathyroid hormone, bone minerals, glucose and insulin hormone levels in Sudanese schizophrenic patients. Method: Descriptive case control study conducted in patients with schizophrenia who were inpatients at two hospitals. One hundred fifty samples were collected, one hundred patients and fifty healthy individuals as controls. Covariates, including patients age, the duration of disease and antipsychotic treatment, other medications that may affect on lipid profiles, plasma parathyroid hormone, bone minerals, glucose and insulin hormone levels. During period from April to November 2013. Results: The means of cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), parathyroid hormone (PTH), calcium, magnesium and glucose were statistically significant differences among patients receiving Olanzapine and Haloperidol, (P<0.05) but were not clinically significant differences. Except in triglyceride, phosphors and insulin in, which was not statistically and clinically significant difference, (P>0.05). A significant positive correlation was noted between the means of lipid profile, plasma parathyroid hormone, bone minerals, glucose and insulin with duration of disease in patients treated with typical and atypical drugs. No significant correlation was noted between the means of lipid profile, parathyroid hormone, bone minerals, glucose and insulin with age of patients treated with typical and atypical drugs. Conclusions: Cholesterol, HDL, LDL, parathyroid hormone, calcium, magnesium and glucose level in schizophrenic patients treated with atypical and typical drugs were clearly higher than that of control. Hence, routine monitoring of lipid profile, parathyroid hormone, bone minerals, glucose and insulin during treatment with antipsychotic drugs is highly recommended for schizophrenic patients.

Keywords: PTH, antipsychotic, Sudan, Cholesterol, Lipids.

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