Pyrex Journal of Biomedical Research (PJBR)

February 2017 Vol. 3 (2), pp. 12-16

ISSN: 2579-1222

Copyright 2017 Pyrex Journals

Full Length Research Paper

Assessment of Prolactin Level Among Sudanese Psychiatric Subjects

Nidal Rabih Mohamed*, Rimaz A. Qurashi and AbdElkarim A. Abdrabo

Department of clinical chemistry, Faculty of Medical Laboratory Science, Al-Neelain University, Sudan.

Corresponding Author E-mail:

Accepted 17th February, 2017


Introduction: Prolactin (PRL) is a polypeptide hormone secreted by the lactotroph cells of the anterior pituitary gland. Prolactin release is pulsatory with approximately 1314 pulses a day and displays a significant diurnal rhythm. Levels increase shortly after sleep onset, peak during the night, and start to decline shortly after waking, reaching a nadir around noon. Some tricyclic antidepressants cause hyperprolactinemia, as do selective serotonin reuptake inhibitors, due to their increased serotonergic stimulatory effects; increases serotonin activity and can produce elevated prolactin levels. So this study aimed to evaluate the prolactin level among Sudanese psychiatric subjects with different diagnosis and treatment, to ascertain the effect on prolactin and to observe the criterion correlated more with high concentration of prolactin, as according to gender, type of mental disorder, treatment and duration of the disease. Method: Enzyme liked immunoassay (ELISA) method used to quantitate prolactin level among 86 Sudanese psychiatric subjects who were diagnosed with bipolar, depression. Schizophrenia and psychosis. Serum concentration of PRL levels measured at Alneelain University, faculty of medical laboratory science. Result: Data obtained showed increased level of PRL among both gender, but no significant different obtained, but according to type of mental disorder as p value 0.001 and 0.015 for bipolar and psychosis respectively, and kind of treatment significant different gained as p value 0.000 for Soduim+olianz and 0.012 for tegretol users. Conclusion: Clear evidence of hyperprolactinaemia among mentally ill subjects.

Keywords: Prolactin, ELISA, serotonin, bipolar. Depression, schizophrenia, psychosis, sodium and olianz.

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