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Pyrex Journal of Biomedical Research (PJBR)

February 2017 Vol. 3 (2), pp. 17-20

ISSN: 2579-1222

Copyright 2017 Pyrex Journals




Full Length Research Paper


Cigarette Smoking is a Risk factor of Renal Functions Impairment


Nizar Mohamed Farah1*, Salih Abdelgadir Elmahdi2, Khalid Gindeel Abu Baker3 and AbdElkarim A. Abdrabo1

1Department of Clinical Chemistry, Faculty of Medical laboratory Sciences- Al-Neelain University, Sudan.

2Department of Clinical Chemistry, Faculty of Medical laboratory Sciences- Alribat National University, Sudan.

3Osman Digna hospital, Ministry of Heath, Port Sudan, Sudan

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 17th February, 2017



Abstract


Recently the adverse effects of smoking on renal function have gained more attention. Therefore, we aim to assess renal biomarkers in cigarette smoking subjects. In this case-control study (n 90) volunteer males, age ranged (22-71) years old were enrolled, (n 60) smokers and (n 30) anon-smoker. Serum Cystatin C, creatinine and urinary Microalbuminuria were measured using fully-automated (Mispa-12, Germany) and (Mindary-380, China) respectively. The Statistical analyses showed that there was a significant difference in means of renal biomarkers of smokers when compared with means of control group, p.value was (0.000, 0.000 and 0.000), respectively, as well as cystatin c and MAU were significantly increased in smoker groups (5-9 years, >10 years), p.values (0.000, 0.000), respectively, meanwhile MAU in the same duration also revealed significant values (0.001, 0.000), respectively. Positive correlations between number of cigarette smoked per day and serum cystatin c, was obtained (p.value= 0.000, r= 0.620), and positive correlations between number of cigarette smoked per day and urinary Microalbuminuria, (p.value= 0.000, r= 0.536). conclusion: cigarette smoking increases the specific renal biomarkers and is risk factor leading to renal impairment.

Keywords: Cigarette, smoke, urine, creatinine.

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