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Pyrex Journal of Biomedical Research (PJBR)

March 2016 Vol. 2(2), pp. 7-10

ISSN: 2985-8852

Copyright 2016 Pyrex Journals




Full Length Research Paper


Evaluation of Chromium and Manganese level in Rheumatoid Arthritis Patients


Sara Yousif Abdalla Arabi1*, SA Elmahdi2, SB Mohamed3, AA Abdrabo1

1University of Al- Neelain, Faculty of Medical Laboratory Sciences, Sudan.
2The National Ribat University, Faculty of Medical Laboratory Sciences, Sudan.
3University of Al–Zawia, Surman, Faculty of Medical Technology, Libya.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 8th March, 2016



Abstract


Background: The importance of trace element in Rh is great of interest because many of these trace elements are co-factors in metabolic processes involving collagen and bone structure, particular tissue or immune system function. In this cross sectional case control study, 55 subjects were studied, 30 of them were RA patients and 25 as healthy controls. The aim of this study was to evaluate the concentration of trace elements (manganese and chromium) in RA patients and apparently healthy control as well as the duration and complications of the disease. Methods: plasma chromium and manganese concentrations were determined using flame atomic absorption spectrophotometer (Buck Scientific 210/211 VGP Atomic Absorption-England). Results: The mean plasma manganese in RA patients when compared vs healthy controls observed statistical insignificant difference, whereas chromium presented, a low significance difference, p.value (0.819, 0.00), respectively. Our result findings reveals statistical insignificance differences in Mn levels in all of the durations period (<5 years, 5-10 years and >10 years), p.value was (0.5, 0.059, 0.48), respectively, while chromium mean levels of patients vs mean control group was significantly lower p.value (0.000, 0.000, 0.000), respectively. The levels of Mn in the 3 complication groups of RA disease (slight complication – moderate complication – sever complication) when compared with mean levels of the healthy control group revealed statistical insignificant, p.value was (0.8), furthermore the mean level of chromium was found significantly decreased among the 3 complication groups p.value (0.02). Conclusion: The mean plasma manganese in RA when compared vs healthy controls found statistical insignificant difference, whereas chromium presented, a low significance difference, p.value (0.819, 0.00), respectively. Chromium mean levels of patients vs mean control group was significantly low p.value (0.000, 0.000, 0.000), respectively. Manganese levels in the 3 complication groups was not statistically different when compared with controls p.value (0.8), chromium was found significantly decreased among the 3 complications groups with p.value (0.02).

Keywords: Rheumatoid arthritis, metabolism, tissues, patients.

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