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Pyrex Journal of Biomedical Research (PJBR)

June 2016 Vol. 2(4), pp. 20-24

ISSN: 2985-8852

Copyright 2016 Pyrex Journals




Full Length Research Paper


Prevalence of Immune Antibodies against red cell among TB Patients in Sokoto, North Western Nigeria


Isaac IZ,1* Imoru M,1 Udomah FP,1 Erhabor O,1 John RT2 and McAnthony I1

1Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto. Nigeria.
2Department of Obstetrics and Gynaecology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Corresponding Author E-mail: isaaczama@yahoo.co.uk

Accepted 3rd May, 2016



Abstract


Background: Tuberculosis (TB) poses significant challenges to developing economies as it primarily affects people during their most productive years. This study is intended to find out the prevalence of immune (IgG) antibodies against red cells among TB patients. Materials and Method: Ninety tuberculosis patients were screened for the presence of IgG autoantibodies against red cells in their plasma. The age range was 18 to 80 years with mean age of 36.8013.074 years. IgG autoantibodies presence was screened by Ortho Biovue system cassettes (AHG/Coombs) technique. Results: The prevalence of IgG autoantibodies among TB patients was 11.1%; (10.0% for those on anti-TB drugs and 1.1% for those not on anti-TB drugs). The Odd Ratio for cohort IgG autoantibodies positive was 0.556. There was no statistical significant difference (P = 0.549) between anti-TB drugs and the prevalence of IgG autoantibodies. Age groups 21-30 and 31-40 years were found to have the highest prevalence of IgG autoantibodies among TB patients. There was however, no statistical significant difference between age groups and the formation of IgG autoantibodies (P = 0.753). The sociodemographic factor also indicates no statistical significant differences (p-values> 0.05). All TB patients with IgG autoantibodies were Hausa tribe. Married, business and illiterates had the highest prevalence (6.7% each), the males were most affected (8.9%) in this study. Conclusion: The study revealed a high prevalence of IgG autoantibodies among tuberculosis patients with 90% of the prevalence among patients on anti-TB drugs.

Keywords: Immune antibodies, red cell, Tuberculosis, Sokoto, Nigeria.

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