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Pyrex Journal of Biomedical Research (PJBR)

June 2016 Vol. 2(4), pp. 25-30

ISSN: 2985-8852

Copyright 2016 Pyrex Journals




Full Length Research Paper


Evaluation of Testosterone and PRL in Type 2 D.M Sudanese Male patients - Khartoum state: a Cross Sectional Study


1Sara A. Osman, 2*Salih A. Elmahdi and 1AbdElkarim A. Abdrabo

1Department of clinical chemistry, Al-Neelain University, Faculty of Medical Laboratory Sciences, Sudan.
2The National Ribat University, Faculty of Medical Laboratory Sciences, Sudan.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 19th May, 2016



Abstract


Background: Diabetes Mellitus Type2 (DM) incidences are increasing worldwide. It accounts for more than 90% of all diabetic patients. The association between low testosterone and DM has recently received considerable attention. Investigators have highlighted the potential metabolic consequences of testosterone decline, showing a potential role of low testosterone on age-associated metabolic changes such as abdominal obesity. Objective: The aim of this study was to evaluate testosterone and prolactin levels among Sudanese men with type 2 DM. Methods: Total testosterone, prolactin and estrogen were quantitatively measured using Automated ELIZA Enzyme Immunoassay Analyzer (AIA-2000). Results: The mean plasma levels of testosterone, prolactin were significantly lower when compared with normal reference value with p.value (0.00, 0.00), respectively, while the mean levels of both Estradiol E2 and BMI observed a statistical significantly higher levels when compared with reference value p.value was (0.000, 0.000), respectively. In this study 37/40(92%) of the patients were overweight, 11/37(29.7%) of those 92% have low testosterone, 10/37(27%) have increased E2 level , and 10/37(27 %) married with no children. Pearson's correlation study between E2 and BMI was found positively correlated as well as between age and duration of disease, r value = (0.89, 0.485), p.value was (0.000, 0.002), respectively and negative correlation findings between E2 and testosterone hormones, and between PRL and BMI, r.value = (-0.68, -0.34) p.value was (0.02, 0.031), respectively. Conclusion: There is an inverse relation between BMI and low testosterone levels, and an obvious relationship between testosterone and E2 among Type 2 diabetic patients with obesity appear to be at a greater risk of low testosterone leading to hypogonadism.

Keywords: PRL, Testosterone, DM, Sudan.

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