Pyrex Journal of Biomedical Research (PJBR)

November 2015 Vol. 1(5), pp. 055-058

Copyright 2015 Pyrex Journals




Original Research Article


Assessment of plasma Alanine Aminotransferase, Aspartate Aminotransferase and Alkaline Phosphatase activity among Sudanese Cannabis abuse People


S Mohamed1*, GA Modawe2, RA Gurashi1, SB Mohamed3, AA Abdrabo1

1AL Neelain University, Faculty of Medical laboratory sciences department of chemical pathology, Khartoum state, Sudan.
2Omdurman Islamic university, Faculty of medicine, Biochemistry department, Sudan.
3Academy of Health Sciences, Medical Laboratory Program, Khartoum-Sudan.

Corresponding Author E-mail: abdrabokarim@hotmail.com

Accepted 16th November, 2015



Abstract


Background: Hepatotoxicity is a potential complication from the usage of various illicit drugs, but information on this scare in the medical literature Objective: The aim of this study was to study the assessment of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and Alkaline Phosphatase (ALP) in chronic Marijuana abusers. Methodology: This is a case control study, conducted in Khartoum State at Alribat Hospital, during May to August 2015.A 120 blood sample was collected, 60 samples of abuse people as case study, 60 samples as control group. The age and sex was matched, which ranged between 18-60 years. Plasma concentration of ALT, AST and ALP were estimated using PS MINDRAY full automation 380. Results: (The means SD) of plasma ALT, AST, and ALP in marijuana abuse people respectively, were (31.117.5), (26.98.2), (77.132.8) IU/ml while in the control group, respectively were (59.710.5), (63.712.4), (169.414.2). Conclusion: This study concludes that chronic abuse of marijuana cause liver hepatotoxicity, because all liver enzymes were highly significant increase when compared with the control group.

Keywords: Marijuana, Hepatotoxicity, Liver enzyme, Sudanese.

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