Pyrex Journal of Biomedical Research (PJBR)

December 2015 Vol. 1(6), pp. 081-085

Copyright 2015 Pyrex Journals




Original Research Article


Lipids Contents Differences in Plasma Phosphatidylcholine of Pregnant And Control Healthy Sudanese Women


Khalil A. KH1* and Ageeb M. SA2

1Department of Basic medical science, College of Medicine, Dar Al Uloom University, Riyadh, Kingdom of Saudi Arabia.
2Department of chemistry, Faculty of Science, Khartoum University, Khartoum, Sudan.

Corresponding Author E-mail: adil76khalil@yahoo.com

Accepted 29th October, 2015



Abstract


Background: Essential fatty acids are polyunsaturated fatty acids (PUFA) which contain more than one double bond. The purpose of this study was to investigate the level of fatty acid composition in plasma phosphatidylcholine of pregnant Sudanese women and healthy control. There were no records about the levels of these fatty acids in Sudanese people. Material and Methods: Blood samples were obtained from the pregnant women at delivery time in Khartoum state hospitals. Full and detailed history and examinations were performed in the study groups. Plasma lipids were extracted by Folch method and separated by Gas Liquid Chromatography (GLC). Results: These results were expressed as mean and standard deviations. Regarding saturated fatty acids (palmitic acid)was higher among pregnant ladieswhile (staeric, myristic and arachidic) were higher among the control group ( p≤0.001).There were significantly higher level of Docosapentaenoic acid (DPA), Docosahexaenoic acid (DHA), linoleic acid (L.A), Arachidonic acid (A.A), total omega-3 (w-3), total omega-6 (w-6) and total w-3/total w-6 ratio (w-3/w6) ratio in control (p≤0.001), whereas significantly higher level of alpha linolenic acid (ALA), Di homogamma linoleic acid (DHGLA) and Adrenic Acid in pregnant female (p≤0.001). Conclusion: The levels of essential fatty acids in our groups were lower than the international levels, except for LA which was higher in comparison to some countries and lower in comparison to theirs. There were differences in concentration of essential fatty acids between pregnant and non pregnant females. The DHA level of the pregnant women was the lowest level being measured which affects the neonatal DHA level.

Keywords: DHA Docosahexaenoic Acid, LCPUFA Long Chain Polyunsaturated Acid, H.C Head Circumference, E.F.A Essential Fatty Acids, AA Arachidonic Acid, LA Linoliec Acid.

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