Pyrex Journal of Biomedical Research (PJBR)

December 2015 Vol. 1(6), pp. 068-073

Copyright 2015 Pyrex Journals




Original Research Article


DNA fragmentation and apoptosis caused by gasoline inhalation, and the protective role of green tea and curcumin


Ata Sedik Ibrahim Elsayed

Department of Biomedical Sciences, Faculty of Medicine, Dar Al Uloom University, Riyadh, Kingdom of Saudi Arabia.

Corresponding Author E-mail: ata4121967@hotmail.com

Accepted 23rd November, 2015



Abstract


This study aimed to investigate the toxic effects of gasoline on DNA in spleen and liver, on the other hand, studying the protective and the ameliorative role of some natural products on these toxic effects of gasoline. Green tea extract and powdered curcumin were chosen as antitoxicity natural products. CD1 mice were taken as an experimental model. Mice were exposed to gasoline vapor 2hours/day for 3 weeks in inhalation chamber. The concentration of gasoline is 9375 ppm and the concentration of benzene is 100 fold less than gasoline in equilibrium with pure benzene being 93.75 ppm. Green tea extract was provided to mice as their sole source of drinking water, and powdered curcumin was added to the diet, these were taken before starting inhalation with one week and along the time of experiment till sacrificing the animals. The study concluded that DNA fragmentation occurred as a result of gasoline toxicity in spleen and liver, these were protected by green tea and curcumin.

Keywords: Gasoline, DNA, green tea, curcumin.

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